Cytotoxic Sphingosine 4-Sulfates from the Sponge Spirastrella abata
- 21 May 2002
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 65 (6), 944-945
- https://doi.org/10.1021/np010312v
Abstract
Two new sphingosine 4-sulfates (1 and 2) have been isolated from the sponge Spirastrella abata as cytotoxic constituents. The gross structures of 1 and 2 were determined by spectroscopic analysis, and their stereochemistry was established by chemical conversion. The compounds exhibited significant cytotoxicity against a small panel of five human tumor cell lines.Keywords
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