Agammaglobulinemia and Bronchiectasis

Abstract

IN 1952 Bruton¹ reported the first case of agammaglobulinemia in an eight-year-old boy. The absence of antibody formation was illustrated by infection with the virus of epidemic parotitis three times, failure to acquire a negative Schick test after repeated injections of diphtheria toxoid and failure to develop immune bodies after injection of pneumococcal polysaccharides and killed typhoid bacteria. The total serum protein was 6.65 gm., the albumin 4.07 gm., and the globulin 2.58 gm. per 100 cc. Electrophoretic studies showed that there was no gamma globulin. Treatment with parenteral administration of gamma globulin was apparently successful in preventing new infections. . . .