Tripelennamine Dysuria in Chronic Nephritic Uremia

Abstract

ACCORDING to recent estimates as many as 10,000,000 people will be taking antihistamines in the United States this year,¹ and 6 to 16 per cent of them will experience side-reactions.² Among the less well known reactions accompanying the use of these agents is difficulty in initiating and maintaining the urinary stream, with associated symptoms of urinary obstruction. In 1949 Wolfson³ reported the occurrence of urinary obstruction in a patient who received tripelennamine. Although reference has been made to this untoward effect^{1 , 2 , 4 5 6 7 8} in the literature, no other case reports for this agent were found. Physicians' awareness of this disturbing symptom may . . .