Comparison of the prevalence of fructose and lactose malabsorption across chronic intestinal disorders
- 26 June 2009
- journal article
- research article
- Published by Wiley in Alimentary Pharmacology & Therapeutics
- Vol. 30 (2), 165-174
- https://doi.org/10.1111/j.1365-2036.2009.04018.x
Abstract
Fructose malabsorption, lactose malabsorption and an early rise in breath hydrogen after lactulose (ERBHAL) may play roles in induction of symptoms in gastrointestinal conditions. To compare prevalence and interactions of fructose malabsorption, lactose malabsorption and ERBHAL among healthy subjects and those with chronic intestinal disorders using consistent breath hydrogen testing methodologies. Consecutive series of Caucasian patients with Crohn's disease (n = 91), ulcerative colitis (56), functional gastrointestinal disorders (FGID) (201), coeliac disease (136) and 71 healthy volunteers underwent breath hydrogen testing using lactulose, fructose and lactose. Early rise in breath hydrogen after lactulose occurred more commonly in healthy controls (39%) than in Crohn's disease (20%) and untreated coeliac disease (14%; P < 0.008), but not FGID (27%), ulcerative colitis (26%) or treated coeliac disease (29%). Fructose malabsorption was more frequent in Crohn's disease (61%) than other groups (33-44%, P < 0.05). Lactose malabsorption was most common in Crohn's disease (42%) and ulcerative colitis (40%) and uncommon (10%) in 79 patients with newly diagnosed coeliac disease. In Crohn's disease, concurrent Fructose malabsorption and lactose malabsorption was most common (29%), and the association of fructose malabsorption with ERBHAL seen overall (62%) was not observed (36%, P < 0.0001). Carbohydrate malabsorption and ERBHAL are normal physiological phenomena. The abnormal patterns observed in Crohn's disease may have pathogenic importance.Keywords
This publication has 62 references indexed in Scilit:
- Bacterial Overgrowth and Irritable Bowel Syndrome: Unifying Hypothesis or a Spurious Consequence of Proton Pump Inhibitors?American Journal of Gastroenterology, 2008
- Fructose Intolerance in IBS and Utility of Fructose-Restricted DietJournal of Clinical Gastroenterology, 2008
- Comparison of breath testing with fructose and high fructose corn syrups in health and IBSNeurogastroenterology & Motility, 2008
- Bacterial metabolism and health-related effects of galacto-oligosaccharides and other prebioticsJournal of Applied Microbiology, 2007
- Ability of the Normal Human Small Intestine to Absorb Fructose: Evaluation by Breath TestingClinical Gastroenterology and Hepatology, 2007
- Sugar malabsorption in functional abdominal bloating: A pilot study on the long-term effect of dietary treatmentClinical Nutrition, 2006
- Prevalence of lactose maldigestionDigestive Diseases and Sciences, 1994
- Revised criteria for diagnosis of coeliac disease. Report of Working Group of European Society of Paediatric Gastroenterology and Nutrition.Archives of Disease in Childhood, 1990
- Sugar absorption by small bowel biopsy samples from patients with primary lactase deficiency and with adult celiac diseaseDigestive Diseases and Sciences, 1976
- Lactose intolerance in childhood coeliac disease. Assessment of its incidence and importance.Archives of Disease in Childhood, 1968