Serum Protein Alterations in Uremia

Abstract

ATTEMPTS to correlate the clinical course of uremic patients with changes in certain serum constituents have been unsuccessful.¹ Similarly, efforts to link the development of uremia to specific "toxins" have been inconclusive.^{2 , 3} To date, no etiologic factor has been identified for the uremic state⁴ — irrespective of any possible relation between diverse mechanisms that terminate in uremia — that is, "renal failure with retention of nitrogenous catabolites."⁵ In a previous study reported from this laboratory, uremia was produced in dogs by bilateral ureteral ligation.⁶ In these animals it was demonstrated by filter-paper electrophoresis that prolongation of the uremic state effected . . .