Plasma Pepsinogen in Peptic-Ulcer Disease and Other Gastric Disorders

Abstract

PEPSIN consists of a protein molecule that may be crystallized out of a solution of crystallin pepsinogen after incubation at pH 4.65. It is a powerful proteolytic enzyme implicated as a causative agent in peptic-ulcer disease, in which it is often associated with an elevated gastric acidity. However, its relation to the chloride ion in gastric juice is not a linear one, and occasionally in ulcer disease the pepsin will be normal or low in the gastric juice when the acidity is high and vice versa. This does not seem remarkable when one considers the various modes of stimulation of . . .