A-16686, a new antibiotic from actinoplanes II. Biological properties.
- 1 January 1984
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 37 (4), 318-324
- https://doi.org/10.7164/antibiotics.37.318
Abstract
A-16686, a new glycoproteide antibiotic obtained from fermentation of an Actinoplanes strain, is active against Gram-positive aerobic and anaerobic bacteria; MIC values ranged from 0.016 to 2.0 μg/ml. A-16686 is bactericidal for growing cells of Staphylococcus aureus, S. epidermidis, Streptococcus faecalis, S. faecium, S. mutans, S. mitis and S. sanguis. There is no cross-resistance with clinically used antibiotics. A-16686, administered subcutaneously, is very effective in experimental S. pyogenes and S. pneumoniae septicemias in the mouse.This publication has 2 references indexed in Scilit:
- A-16686, a new antibiotic from Actinoplanes I. Fermentation, isolation and preliminary physico-chemical characteristics.The Journal of Antibiotics, 1984
- Teichomycin: in-vitro and in-vivo evaluation in comparison with other antibioticsJournal of Antimicrobial Chemotherapy, 1983