Therapeutic Effects of Ribavirin Given by the Intraperitoneal or Aerosol Route Against Influenza Virus Infections in Mice
Open Access
- 1 September 1976
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 10 (3), 549-554
- https://doi.org/10.1128/aac.10.3.549
Abstract
Ribavirin (1-β- d -ribofuranosyl-1,2,4-triazole-3-carboxamide) is an effective antiviral agent against type A influenza infection of mice. Therapy was most effective when administered as a small-particle aerosol early in the infection. Treatment was also effective by either the intraperitoneal or aerosol route in mice with histological evidence of pneumonia. Ribavirin increased the percent survival, lowered lung virus titers, and decreased the development of lung pathology when therapy was initiated at 6 h as a small-particle aerosol. There was no evidence of pulmonary toxicity or immunosuppressive effects.Keywords
This publication has 12 references indexed in Scilit:
- Small-Particle Aerosols of Antiviral Compounds in Treatment of Type A Influenza Pneumonia in MiceThe Journal of Infectious Diseases, 1976
- Treatment of Influenza Infection of Mice by Using Rimantadine Hydrochlorides by the Aerosol and Intraperitoneal RoutesAntimicrobial Agents and Chemotherapy, 1975
- Efficacy of 1-β- d -Ribofuranosyl-1,2,4-Triazole-3-carboxamide Against Influenza Virus Infections in MiceAntimicrobial Agents and Chemotherapy, 1975
- Mechanism of Action of Anti-Influenza Benzamidine DerivativesAntimicrobial Agents and Chemotherapy, 1975
- Suppression by 1-β- d -Ribofuranosyl-1,2,4-Triazole-3-Carboxamide (Virazole, ICN 1229) of Influenza Virus-Induced Infections in MiceAntimicrobial Agents and Chemotherapy, 1973
- Effect of 1-β- d -Ribofuranosyl-1,2,4-Triazole-3-Carboxamide (Virazole, ICN 1229) on Herpes and Vaccinia Keratitis and Encephalitis in Laboratory AnimalsAntimicrobial Agents and Chemotherapy, 1973
- In Vitro Effect of 1-β- d -Ribofuranosyl-1,2,4-Triazole-3-Carboxamide (Virazole, ICN 1229) on Deoxyribonucleic Acid and Ribonucleic Acid VirusesAntimicrobial Agents and Chemotherapy, 1973
- Design, synthesis, and broad spectrum antiviral activity of 1-.beta.-D-ribofuranosyl-1,2,4-triazole-3-carboxamide and related nucleosidesJournal of Medicinal Chemistry, 1972
- Modifications to the Henderson Apparatus for Studying Air-Borne Infections. Evaluations Using Aerosols of Listeria MonocytogenesThe Journal of Infectious Diseases, 1962
- STUDIES IN EXPERIMENTAL IMMUNOLOGY OF INFLUENZAImmunology & Cell Biology, 1950