THE INHIBITION OF THE PROLIFERATION OF COWPOX VIRUS IN EMBRYONATED HENS' EGGS BY CORTISONE

Abstract

Titration of infective particles in the chorioallantoic membranes from embryonated hens'' eggs showed that cortisone treatment inhibits the growth of the cowpox virus. This effect was demonstrable not earlier than 48 hours after inoculation, when the dose was 2.5 mg and not earlier than 72 hours when the dose was 0.1 mg. There was no demonstrable effect after 0.01 mg. The results confirm previous morphological investigations and were interpreted as the results of a general inhibition of the synthesis of virus protein independent of the type of the nucleic acid component of the viruses.