Nitrones as dipoles for rapid strain-promoted 1,3-dipolar cycloadditions with cyclooctynes
- 23 December 2009
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- Vol. 46 (6), 931-933
- https://doi.org/10.1039/b921630h
Abstract
Strain-promoted cycloadditions of nitrones with cyclooctynes (k2 = 1.5 M−1 s−1 at 25 °C) are up to 25 times more rapid than comparable reactions of azides.Keywords
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