Renal Function During Arterial Hypertension Produced by Chronic Splanchnic Nerve Stimulation in the Dog

Abstract

Chronic splanchnic nerve stimulation was carried out on 6 dogs for periods ranging from 12-41 days. Blood pressure, pulse rate and renal function were observed. Blood pressure remained elevated only for the duration of the stimulus. Pulse rate during hypertension was normal. Renal plasma flow, glomerular filtration and filtration fraction were increased during hypertension in some instances. No animal showed a distinct decrease in RPF and GF. Taken as a group, the animals studied revealed no statistically significant alteration in renal function during hypertension. Renal vasoconstriction sufficient to maintain renal blood flow constant during hypertension was evident in most cases. Renal ischemia as a cause of hypertension in these expts. was not established. Hypertension was probably produced by vasoconstriction of the splanchnic bed.