Biology and pharmacology of recombinant human interleukin-1β-induced rat ear inflammation
- 1 August 1987
- journal article
- Published by Springer Nature in Inflammation Research
- Vol. 21 (3-4), 325-327
- https://doi.org/10.1007/bf01966505
Abstract
A single, 10 ng intradermal injection of human recombinant interleukin-1β (rIL-1β) into rat ears produced acute inflammation. Tissue wet weight (edema) and total myeloperoxidase activity (PMN accumulation), peaked at 3 hours and returned to base line at 3 days. Given orally, 1 hour prior to rIL-1β injection, cyproheptadine, dexamethasone, conventional NSAID's, or mixed cyclooxygenase/lipoxygenase inhibitors were potent antagonists of edema and moderate antagonists of PMN accumulation. In addition, the putative DMARD's, auranofin, dapsone, and levamisole were effective inhibitors of rIL-1β induced inflammation.Keywords
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