Structure-activity relationships of carbocyclic influenza neuraminidase inhibitors
- 22 July 1997
- journal article
- Published by Elsevier in Bioorganic & Medicinal Chemistry Letters
- Vol. 7 (14), 1837-1842
- https://doi.org/10.1016/s0960-894x(97)00333-8
Abstract
No abstract availableKeywords
This publication has 15 references indexed in Scilit:
- Influenza Neuraminidase Inhibitors Possessing a Novel Hydrophobic Interaction in the Enzyme Active Site: Design, Synthesis, and Structural Analysis of Carbocyclic Sialic Acid Analogues with Potent Anti-Influenza ActivityJournal of the American Chemical Society, 1997
- Novel inhibitors of influenza sialidases related to GG167 structure-activity, crystallographic and Molecular dynamics studies with 4H-pyran-2-carboxylic acid 6-carboxamidesBioorganic & Medicinal Chemistry Letters, 1996
- Novel inhibitors of influenza sialidase related to GG167 Synthesis of 4-amino and guanidino-4H-pyran-2-carboxylic acid-6-propylamides; selective inhibitors of influenza a virus sialidaseBioorganic & Medicinal Chemistry Letters, 1996
- Safety and efficacy of the neuraminidase inhibitor GG167 in experimental human influenzaPublished by American Medical Association (AMA) ,1996
- GG167 (4-guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid) is a potent inhibitor of influenza virus in ferretsAntimicrobial Agents and Chemotherapy, 1995
- Approaches to carbocyclic analogues of the potent neuraminidase inhibitor 4-guanidino-Neu5Ac2en. X-Ray molecular structure of N-[(1S,2S,6R)-2-azido-6-benzyloxymethyl-4-formylcyclohex-3-enyl]acetamideJournal of the Chemical Society, Perkin Transactions 1, 1995
- Inhibition of influenza virus replication in mice by GG167 (4-guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid) is consistent with extracellular activity of viral neuraminidase (sialidase)Antimicrobial Agents and Chemotherapy, 1994
- Molecular Modeling Studies on Ligand Binding to Sialidase from Influenza Virus and the Mechanism of CatalysisJournal of Medicinal Chemistry, 1994
- 4-Guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid is a highly effective inhibitor both of the sialidase (neuraminidase) and of growth of a wide range of influenza A and B viruses in vitroAntimicrobial Agents and Chemotherapy, 1993
- A Simple Synthesis of Alkyl FormimidatesAngewandte Chemie International Edition in English, 1967