Sterol‐polyene antibiotic complexation: Probe of membrane structure
- 1 October 1978
- Vol. 13 (10), 686-691
- https://doi.org/10.1007/bf02533746
Abstract
Polyene antibiotics are useful tools for studying the role of sterols in biological membranes. The interaction of polyene antibiotics with membrane-bound sterols in artificial membrane systems, prokaryotic and eukaryotic cells, and lipid-containing viruses is reviewed. The pentaene macrolide, filipin, is shown to serve as a probe of phosphatidylcholine-sterol interaction and of the localization of cholesterol in the membrane of mycoplasmas.Keywords
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