Phosphonoacetic Acid in the Treatment of Experimental Ocular Herpes Simplex Infections
- 1 February 1976
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 9 (2), 308-311
- https://doi.org/10.1128/aac.9.2.308
Abstract
Phosphonoacetic acid had a significant antiviral effect when applied topically, both in liquid and ointment preparations, on superficial herpetic keratitis in rabbits and was equally as effective as idoxuridine. It was also effective in the treatment of idoxuridine-resistant herpetic keratitis. Phosphonoacetic acid was not effective in the treatment of experimental herpetic iritis when applied topically but was significantly effective when administered intravenously and subconjunctivally. No significant local or systemic toxicity was encountered.Keywords
This publication has 7 references indexed in Scilit:
- Intravenous Adenine Arabinoside Against Herpes Simplex Keratouveitis in HumansAmerican Journal of Ophthalmology, 1975
- Phosphonoacetic Acid-Resistant Herpes Simplex Virus Infection in Hairless MiceAntimicrobial Agents and Chemotherapy, 1975
- Phosphonoacetic Acid in the Treatment of Experimental Herpes Simplex KeratitisAntimicrobial Agents and Chemotherapy, 1975
- Inhibition of Herpes Simplex Virus Replication by Phosphonoacetic AcidAntimicrobial Agents and Chemotherapy, 1974
- Suppression of herpes simplex virus infection by phosphonoacetic acid.1973
- Trifluorothymidine treatment of herpetic iritis in rabbits and ocular penetration.1973
- DEVELOPMENT OF RESISTANCE TO ANTIVIRAL DRUGSAnnals of the New York Academy of Sciences, 1965