PATERNAL AGE AND DOWN SYNDROME IN BRITISH-COLUMBIA
- 1 January 1981
- journal article
- research article
- Vol. 33 (1), 123-128
Abstract
Among Down''s syndrome cases born in 1964-1976 reported to the British Columbia Registry for Handicapped Children [Canada], the mean paternal age was about half a year greater than in the entire population of live births after controlling for maternal age, a difference significant at the 0.05 level. After adjustment for maternal age, a regression analysis was consistent with an increase of 1.024-fold for each year of paternal age. Among Down''s syndrome cases in 1952-1963, however, for which ascertainment appears to be less than complete, there was no evidence for a significant paternal age effect. The reasons for the variation between the 2 groups investigated here and the heterogeneity in results among studies of other populations are discussed.This publication has 12 references indexed in Scilit:
- Where have all the editorialists gone?1981
- PATERNAL AGE AND DOWN SYNDROME1979
- Frequency of down syndrome in livebirths by single-year maternal age interval: Results of a Massachusetts studyTeratology, 1978
- DOWN SYNDROME IN LIVE BIRTHS BY SINGLE YEAR MATERNAL AGE INTERVAL IN A SWEDISH STUDY - COMPARISON WITH RESULTS FROM A NEW-YORK STATE STUDY1978
- Reexamination of paternal age effect in Down's syndromeHuman Genetics, 1978
- The origin of the extra chromosome 21 in Down syndromeCytogenetic and Genome Research, 1978
- Paternal age effect in Down's syndromeAnnals of Human Genetics, 1977
- Down syndrome in british columbia, 1952-73: Incidence and mean maternal ageTeratology, 1976
- The British Columbia Registry for Handicapped Children and Adults: evolutionary changes over twenty years.1975
- Paternal age in Down's syndrome.1967