Metabolic Reduction of 1-(p-Acetylbenzenesulfonyl)-3-cyclohexylurea (Acetohexamide) in Different Species

Abstract

Metabolism of acetohexamide was investigated in dogs, rabbits, rats, and man. Trace amounts of unchanged drug were found in the urine of dogs and man. All species excreted the reduced form, 1-(p-a-hydroxy-ethyi-benezenesulfonyl)-3-cyclohexylurea. From the urine of dog, rabbit, and man 49-59% of orally administered drug was recovered as metabolite, but only 18% from the urine of the rat. Chromatograms of rat urine revealed no other metabolites.