Allogeneic marrow transplantation for chronic granulocytic leukemia
- 1 October 1982
- journal article
- research article
- Published by Springer Nature in Blut: Zeitschrift für die Gesamte Blutforschung
- Vol. 45 (4), 237-242
- https://doi.org/10.1007/bf00320190
Abstract
Six patients with Philadelphia-chromosome (Ph' +)-positive chronic granulocytic leukemia were transplanted from their HLA-identical siblings after conditioning with cyclophosphamide and 1'000 rad total body irradiation. All received cyclosporin-A for prophylaxis of Graft-versus-Host disease. All patients showed prompt engraftment and all are cytogenetically and clinically in complete remission. Two patients had transient mild signs of Graft-versus-Host-disease and one patient had unilateral facial nerve paresis of unknown origin. All are ambulatory and well 6–18 months (median 10 months) after transplantation.Keywords
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