HYDROCORTISONE‐INDUCED INHIBITOR OF PROSTAGLANDIN BIOSYNTHESIS IN RAT LEUCOCYTES
Open Access
- 1 January 1980
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 68 (1), 14-16
- https://doi.org/10.1111/j.1476-5381.1980.tb10691.x
Abstract
Rat peritoneal leucocytes incubated with hydrocortisone (10 μg/ml) release a factor which inhibits prostaglandin generation. The steroid-induced inhibitor, which mediates the anti-phospholipase effect of anti-inflammatory steroids, may be a protein or a polypeptide since its formation is blocked by cycloheximide, a known inhibitor of protein synthesis.Keywords
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