Studies on the Serology of Renal Diseases II.

Abstract

Serum of a patient with chronic glomerulonephritis contained antibodies which combined with antigens of normal kidney and other organs. These antigens could be detected in tissue extracts prepared by prolonged autolysis, urea treatment or sodium deoxycholate treatment but not in plain saline extracts of tissues. Related antigens were detected in 6 of 70 sera originating from patients with various renal disorders. Of these 6 patients, 4 excreted the antigens in urine. The mutual relationship of the antigens detectable in tissue extracts, serum and urine was discussed.