Effect of α-Tocopherol Status on α-Tocopherol Transfer Protein Expression and Its Messenger RNA Level in Rat Liver
- 1 January 1998
- journal article
- research article
- Published by Taylor & Francis in Free Radical Research
- Vol. 28 (1), 87-92
- https://doi.org/10.3109/10715769809097879
Abstract
Studies were designed to explore the role of vitamin E nutritional status in regulating the synthesis of α-tocopherol transfer protein (αTTP) in rat liver. In vitamin E-replete rats, expression of this protein and its specific messenger RNA (mRNA) was decreased by about 300% compared with rats with normal vitamin E levels. In vitamin E-depleted rats, the αTTP-specific mRNA level increased to about 150% of that in the normal vitamin E group. However, protein expression remained constant. These findings indicate that the synthesis of αTTP can be regulated by the vitamin E nutritional status.Keywords
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