THE HYPERPNEA OF MUSCULAR EXERCISE

Abstract

This review attempts to evaluate the importance of each of the following factors and to estimate the contribution of each to the total hyperpnea of exertion: 1. CO2, lactic acid, and other metabolites formed during exercise. 2. Reflexes arising from the exercising limbs. 3. Chemical receptors in the limbs. 4. Reflexes from the carotid and aortic bodies. 5. Reflexes from the lungs. 6. Reflexes from the great veins and auricle. 7. Increase in body temperature. 8. Adrenalin liberation. 9. Irradiation from the motor cortex. 10. Internal acidity of cells of respiratory center. The author concludes that "probably the most important discovery of the last century[long dash]more important than the finding of any new reflex or chemical stimulant[long dash]has been the realization that respiration is controlled not by reflexes alone, not by chemical -stimulation of the medulla alone, but by the proper interaction of both factors.".