Age of Appearance of IgG, IgM, and IgE Antibodies Specific for Loa loa in Gabonese Children
- 1 July 1984
- journal article
- research article
- Published by Wiley in Microbiology and Immunology
- Vol. 28 (7), 787-792
- https://doi.org/10.1111/j.1348-0421.1984.tb00734.x
Abstract
IgG, IgM and IgE antibodies against the filaria L. loa were measured in umbilical cord blood and in blood from young Gabonese children by an ELISA [enzyme linked immunosorbent assay] technique using a homologous metabolic antigen. For children in 8 consecutive age groups and adults the percentage of the population positive for each of the antibody classes was determined. The number of children with maternal IgG decreased until 1 yr of age when new synthesis began to become apparent. IgM antibodies were detected only after 6 mo., probably indicating an early infancy as opposed to a fetal infection. The percentage of individuals positive for IgM or IgE reached a peak between 2 and 3 yr old, followed by a slight decline. Over half of the individuals over 1 yr of age had IgM antibody against L. loa, indicating long-term synthesis of this class of immunoglobulin in many people. In the first 2 yr of life, IgE antibodies were usually accompanied by L. loa-specific IgM. This specific IgE did not appear to trigger the synthesis of nonspecific IgE. By the age of 2, 95% of the population had some antibodies against L. loa and by 5 the percentage of individuals positive for each antibody class had reached adult levels.This publication has 5 references indexed in Scilit:
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