Isolation of mutagens from bacterial nutrients containing beef extract

Abstract

The enhanced rate of mutation of Salmonella strain TA1538 (Ames) by microsomes results from the presence of about 2–5 ppm of microsome‐activatable mutagens in bacterial nutrient broths that contain beef extract. Since mutagens toward Salmonella are likely to be carcinogenic, the data have significant implications for the problem of carcinogenesis.