Sex differences in the association of abdominal adipose tissue and anthropometric data with untreated hypertension in a Chinese population
Open Access
- 17 July 2020
- journal article
- research article
- Published by Springer Nature in Biology of Sex Differences
- Vol. 11 (1), 1-9
- https://doi.org/10.1186/s13293-020-00317-4
Abstract
There are inconsistent interpretations of the interrelationship of adiposity, anthropometric indices, and blood pressure (BP) in hypertensive patients. Additionally, whether these relationships differ between sexes is unknown. We aimed to elucidate the associations of adiposity indices measured using quantitative computed tomography (QCT) with BP and hypertension and to determine the effect of sex on the interrelationship of these parameters in a Chinese population. Abdominal adipose fat, including the visceral adipose tissue (VAT) area and subcutaneous adipose tissue (SAT) area, was measured by QCT in 1488 patients (514 men, 974 women). Body mass index (BMI), waist circumference (WC), hip circumference (HC), and systolic (SBP) and diastolic BP (DBP) were measured. Pearson correlation coefficients, multivariate analyses, and receiver operating characteristic (ROC) curves were used to assess the relationship and potential of adiposity indices to BP and risk of hypertension within sex groups. Men had significantly greater VAT area but less SAT area than women in hypertensive group. VAT, SAT, and WC were more highly correlated with SBP in men than in women. After controlling for body weight, height, and age, VAT area and WC were positively associated with SBP (VAT: β = 0.309, p < 0.001; WC: β = 0.148, p = 0.001) and DBP (VAT: β = 0.099, p = 0.034; WC: β = 0.198, p = 0.001) in women. VAT area was positively associated with SBP (β = 0.444, p < 0.001) and DBP (β = 0.146, p = 0.021) in men. WC had a significant correlation with an increased risk of hypertension in women but a borderline association in men (p = 0.059) when adjusted for VAT area and SAT area. The association of abdominal adiposity with hypertension differs qualitatively by sex. WC may be an important determinant of hypertension and may be used for risk stratification for hypertension among Chinese individuals.Keywords
Funding Information
- National Natural Science Foundation of China (81700330)
- Beijing Municipal Excellent Talents Foundation (2016000021469G176)
This publication has 33 references indexed in Scilit:
- Is Waist-to-Height Ratio Superior to Body Mass Index and Waist Circumference in Predicting the Incidence of Hypertension?Annals of Nutrition and Metabolism, 2019
- Longitudinal change in blood pressure is associated with cardiovascular disease mortality in a Chinese cohortHeart, 2018
- Comparison of regional fat measurements by dual-energy X-ray absorptiometry and conventional anthropometry and their association with markers of diabetes and cardiovascular disease riskInternational Journal of Obesity, 2017
- Abdominal Adiposity Distribution Quantified by Ultrasound Imaging and Incident Hypertension in a General PopulationHypertension, 2016
- Comparison of visceral and body fat indices and anthropometric measures in relation to untreated hypertension by age and gender among ChineseInternational Journal of Cardiology, 2016
- The association of visceral adipose tissue and subcutaneous adipose tissue with metabolic risk factors in a large population of Chinese adultsClinical Endocrinology, 2016
- Sex and age differences in the effect of obesity on incidence of hypertension in the Japanese population: A large historical cohort studyJournal of the American Society of Hypertension, 2014
- Sex Differences in the Contributions of Visceral and Total Body Fat to Blood Pressure in AdolescenceHypertension, 2012
- Sex differences in the relationships of abdominal fat to cardiovascular disease risk among normal-weight white subjectsInternational Journal of Obesity, 2003
- Sympathetic Neural Activation in Visceral ObesityCirculation, 2002