Optimization of the β-Aminoester class of factor Xa inhibitors. part 1: P4 and side-Chain modifications for improved In vitro potency
- 17 June 2002
- journal article
- research article
- Published by Elsevier in Bioorganic & Medicinal Chemistry Letters
- Vol. 12 (12), 1667-1670
- https://doi.org/10.1016/s0960-894x(02)00212-3
Abstract
No abstract availableKeywords
This publication has 11 references indexed in Scilit:
- Optimization of the β-Aminoester class of factor Xa inhibitors. part 2: Identification of FXV673 as a potent and selective inhibitor with excellent In vivo anticoagulant activityBioorganic & Medicinal Chemistry Letters, 2002
- Recent advances in Factor Xa inhibitorsExpert Opinion on Therapeutic Patents, 2001
- Crystal Structures of Human Factor Xa Complexed with Potent InhibitorsJournal of Medicinal Chemistry, 2000
- Sulfonamidopyrrolidinone Factor Xa Inhibitors: Potency and Selectivity Enhancements via P-1 and P-4 OptimizationJournal of Medicinal Chemistry, 1999
- Factor Xa inhibitorsExpert Opinion on Therapeutic Patents, 1999
- Progress in the design of inhibitors of coagulation factor XaDrugs of the Future, 1999
- Identification and Initial Structure−Activity Relationships of a Novel Class of Nonpeptide Inhibitors of Blood Coagulation Factor XaJournal of Medicinal Chemistry, 1998
- Factor Xa Inhibitors as Novel Antithrombotic Agents: Facts and PerspectivesCardiovascular Drug Reviews, 1994
- The coagulation cascade: initiation, maintenance, and regulationBiochemistry, 1991
- Asymmetric synthesis of R-β-amino butanoic acid and S-β-tyrosine: Homochiral lithium amide equivalents for Michael additions to α,β-unsaturated esters.Tetrahedron: Asymmetry, 1991