Optimization of the β-Aminoester class of factor Xa inhibitors. part 2: Identification of FXV673 as a potent and selective inhibitor with excellent In vivo anticoagulant activity
- 17 June 2002
- journal article
- research article
- Published by Elsevier in Bioorganic & Medicinal Chemistry Letters
- Vol. 12 (12), 1671-1674
- https://doi.org/10.1016/s0960-894x(02)00213-5
Abstract
No abstract availableKeywords
This publication has 18 references indexed in Scilit:
- Optimization of the β-Aminoester class of factor Xa inhibitors. part 1: P4 and side-Chain modifications for improved In vitro potencyBioorganic & Medicinal Chemistry Letters, 2002
- Novastan®(Brand of Argatroban): A Small-Molecule, Direct Thrombin InhibitorSeminars in Thrombosis and Hemostasis, 1997
- New Data on the Pharmacology of Heparin and Low Molecular Weight HeparinsDrugs, 1996
- Clotting for the clinician: An overview of thrombosis and antithrombotic therapyJournal of Thrombosis and Thrombolysis, 1995
- Membrane-dependent reactions in blood coagulation: role of the vitamin K-dependent enzyme complexesBiochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1994
- Factor Xa Inhibitors as Novel Antithrombotic Agents: Facts and PerspectivesCardiovascular Drug Reviews, 1994
- Evidence for a rebound coagulation phenomenon after cessation of a 4-hour infusion of a specific thrombin inhibitor in patients with unstable angina pectorisJournal of the American College of Cardiology, 1993
- Oral Anticoagulants: Pharmacodynamics, Clinical Indications and Adverse EffectsThe Journal of Clinical Pharmacology, 1992
- The coagulation cascade: initiation, maintenance, and regulationBiochemistry, 1991
- Unstable angina with fatal outcome: dynamic coronary thrombosis leading to infarction and/or sudden death. Autopsy evidence of recurrent mural thrombosis with peripheral embolization culminating in total vascular occlusion.Circulation, 1985