The Effects of Pyromen Administered Intravenously in Subpyrexial Doses to Depressed Patients

Abstract

PYROMEN is a sterile, nonprotein, nonana-phylactogenic extract of Pseudomonas aemginosa and Proteus vulgaris prepared as a colloidal dispersion in normal saline for intravenous use.^{1 , 2} Pharmacologically, it is a pyrogen of a high degree of reliability and a low order of toxicity. Chemical analysis has identified it as a complex polysaccharide.^{1 2 3 4} Study of the histologie and physiologic effects in animals revealed some ACTH-like effects.^{3 4 5 6} Clinical evaluation was directed toward its efficacy not only as a pyrexial agent but also as a stimulant of the pituitary-adrenal axis in those diseases believed to respond to ACTH.^{7 8 9 10 11} In certain allergic states it proved beneficial . . .