Genes in mice that affect susceptibility to cortisone-induced cleft palate are closely linked to Ir genes on chromosomes 2 and 17.

Abstract

Inbred and congeneic strains of mice were examined for susceptibility to cortisone-induced cleft palate and the role of genes linked to H-2 on chromosome 17 was confirmed. Increasing degrees of susceptibility were associated with the H-2d, H-2k and H-2a haplotypes, respectively, with H-2q and H-28 being associated with fairly high levels of susceptibility. One gene evidently maps with the B region of H-2 and a 2nd H-2-linked gene which acts by complementation maps to the right of E. Another gene affecting this trait is closely linked to the H-3 and Ir-2 loci on the 2nd chromosome.