ACID INHIBITION OF THE INTESTINAL AND INTRAGASTRIC CHEMICAL PHASES OF GASTRIC SECRETION

Abstract

The intestinal phase of acid secretion is not inhibited by the presence of N/10HCl in the stomach. As the acid leaves the stomach and passes into the intestine, the intestinal phase is promptly and completely inhibited. When the intestinal and intragastric chemical phases are simultaneously combined, the presence of N/10HCl in the stomach and intestine is usually not able to inhibit acid secretion. A theory of the regulation of gastric acidity by acid inhibition is presented. Shifts in the threshold for acid inhibition may be the cause of certain abnormalities of acid secretion. By means of acid inhibition, it is theoretically possible for gastric acidity to be adequately regulated in the absence of duodenal regurgitation.