The Use of the Mouse in Studies on Streptomycin
- 1 January 1947
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 64 (1), 22-25
- https://doi.org/10.3181/00379727-64-15687
Abstract
Whereas streptomycin is absorbed and excreted considerably faster in mice than in man, the percentage recovery of streptomycin in the urine of these 2 spp. is very similar. Hence, there is no reason to believe that this antibiotic is destroyed in the mouse to any greater extent than in man. Despite the fact that streptomycin is adsorbed on alkaline alumina, streptomycin administered in mixture with alkaline K aluminum sulfate is excreted as rapidly in mice as is streptomycin given alone.Keywords
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