Genome-wide association study of panic disorder in the Japanese population
- 23 January 2009
- journal article
- Published by Springer Nature in Journal of Human Genetics
- Vol. 54 (2), 122-126
- https://doi.org/10.1038/jhg.2008.17
Abstract
Panic disorder (PD) is an anxiety disorder characterized by panic attacks and anticipatory anxiety. Although a number of association studies have been conducted, no gene has been identified as a susceptibility locus. In this study, we conducted a genome-wide association study of PD in 200 Japanese patients and the same number of controls, using the GeneChip Human Mapping 500 K Array Set. Genotypes were determined using the Bayesian Robust Linear Model with Mahalanobis (BRLMM) genotype calling algorithm. The genotype data were data-cleaned using criteria for SNP call rate (95%), Hardy–Weinberg equilibrium (P0.1%) and minor allele frequency (5%). The significance level of the allele P-value was set at 1.0 × 10−6, to make false discovery rate (FDR) PKP1, PLEKHG1, TMEM16B, CALCOCO1, SDK2 and CLU (or APO-J). Studies with other samples are required to confirm the results.Keywords
This publication has 18 references indexed in Scilit:
- The association between panic disorder and the L/L genotype of catechol-O-methyltransferaseJournal of Psychiatric Research, 2004
- Association study of serotonin-2A receptor gene polymorphism and panic disorder in patients from Canada and GermanyNeuroscience Letters, 2004
- Positive association between panic disorder and polymorphism of the serotonin 2A receptor genePsychiatry Research, 2003
- Transcriptional activities of cholecystokinin promoter haplotypes and their relevance to panic disorder susceptibilityAmerican Journal of Medical Genetics, 2002
- CatecholO-Methyltransferase Genetic Polymorphism in Panic DisorderAmerican Journal of Psychiatry, 2002
- Evidence for a susceptibility locus for panic disorder near the catechol-O-methyltransferase gene on chromosome 22Biological Psychiatry, 2002
- Association studies of the CT repeat polymorphism in the 5′ upstream region of the cholecystokinin B receptor gene with panic disorder and schizophrenia in Japanese subjectsAmerican Journal of Medical Genetics, 2001
- Association of a functional −1019C>G 5-HT1A receptor gene polymorphism with panic disorder with agoraphobiaInternational Journal of Neuropsychopharmacology, 1999
- Systematic mutation screening and association study of the A1 and A2a adenosine receptor genes in panic disorder suggest a contribution of the A2a gene to the development of diseaseMolecular Psychiatry, 1998
- Panic and panic disorder in the United StatesAmerican Journal of Psychiatry, 1994