METABOLIC CHANGES IN TRAUMA-RESISTANT RATS FOLLOWING TRAUMA

Abstract

Some metabolites were followed in rats which had been made resistant to trauma by exposure to Noble-Collip drum injury. In trauma-resistant rats liver glycogen levels are 50% lower than in control animals. If trauma-resistant rats are subjected to trauma that does not kill control animals then the metabolic response during the first 2 hours after trauma, determined by measuring changes in blood glucose, pyruvic acid, amino nitrogen, urea, and total acetone bodies, differs from that of control animals only by being less pronounced quantitatively. The course of metabolic changes in trauma-resistant rats differs considerably from that of control animals between the 2d and 24th hour after trauma, especially in the levels of acetone bodies and urea in the blood. The development of the resistance to trauma is''accompanied by a change in the metabolic response to trauma.