THE ESSENTIAL LESION IN EXPERIMENTAL DIABETES INSIPIDUS

Abstract

WE HAVE stated (1941) that the von Hann view that diabetes insipidus (DI) cannot occur in the absence of pars distalis is incorrect, since sustained DI occurred in dogs as a result of total hypophysectomy, and persisted after removal of the pars distalis where DI had been produced by denervation of the neurohypophysis, complete absence of pars distalis being proved by serial sections. The present report confirms and extends these findings, offers an explanation for the apparent discrepancies in other workers' findings, and reports further observations on other endocrine influences on renal water output.