Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines
- 1 October 1984
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 311 (5988), 727-733
- https://doi.org/10.1038/311727a0
Abstract
The most JH-proximal VH gene segments are used highly preferentially to form VHDJH rearrangements in pre-B-cell lines. This result demonstrates that the rate at which immunoglobulin VH gene segments recombine is influenced by their chromosomal organization, and that the initial repertoire ofVH genes expressed in pre-B cells is strikingly different from that seen in mature populations.This publication has 31 references indexed in Scilit:
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