Dynamics of Gastric Acid Inhibition by Ranitidine in Duodenal Ulcer Patients
- 1 January 1981
- journal article
- research article
- Published by S. Karger AG in Digestion
- Vol. 22 (3), 119-125
- https://doi.org/10.1159/000198617
Abstract
The dynamics of the inhibitory effect of ranitidine, a new H2-receptor antagonist, on histamine and pentagastrin-induced gastric secretion have been examined in duodenal ulcer patients. The inhibition by ranitidine of histamine-induced secretion was found to be competitive, whereas that of pentagastrin-induced secretion not competitive. Ranitidine was an effective inhibitor of pentagastrin-induced secretion for 8–12 h after administration. The availability of ranitidine, a powerful and long-acting inhibitor of gastric secretion, provides an opportunity of an alternative treatment from cimetidine for peptic ulcer and related diseases.This publication has 7 references indexed in Scilit:
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