Serum Lipids and Their Value in Diagnosis

Abstract

Normocholesteremia and Foam-Cell Formation Increased xanthoma formation in essential xanthomatosis of the normocholesteremic type. This condition is synonymous with Schüller—Christian disease, lipid granulomatosis, eosinophilic granuloma and eosinophilic xanthomatous granuloma. Pinkus and Pick^{87 , 88} were the first to discover that the fat substances in the foam cells are cholesterol and cholesterol esters. These authors advanced the theory that cholesterol infiltration of certain cells takes place because of an increased cholesterol supply from the blood. In the syndrome under discussion, xanthoma-cell formation occurs without increased cholesterol supply from the blood — that is, with normal cholesterol values in the serum. Waldeyer⁶⁶ has already . . .