Effect of cholecystokinin octapeptide and vasoactive intestinal polypeptide on adrenocortical secretion in the rat.
- 1 January 1982
- journal article
- research article
- Published by Physiological Society of Japan in The Japanese Journal of Physiology
- Vol. 32 (4), 553-560
- https://doi.org/10.2170/jjphysiol.32.553
Abstract
I.p injection of C-terminal octapeptide of cholecystokinin (CCK-8) produced a dose-related increase in plasma corticosterone levels in intact rats, but not in vagotomized ones. Intracerebroventricular injection of CCK-8 was ineffective in stimulating the secretion of corticosterone, and in vitro experiment on ACTH release indicated that CCK-8 could not affect pituitary tissue directly. Since i.p. injection of non-sulfated CCK-8 failed to elevate plasmas corticosterone levels, sulfated tyrosine residue in the CCK molecule is assumed to be indispensable for the stimulation of visceral organs. On the other hand, vasoactive intestinal polypeptide (VIP) caused a dose-dependent increase in plasma corticosterone levels when administered centrally, but not after i.p. injection. However, VIP could not stimulate the release of ACTH from the pituitary tissue directly. VIP, but not CCK, apparently stimulates the hypothalamic corticotropin releasing factor neurons either directly or indirectly.This publication has 11 references indexed in Scilit:
- Circadian rhythm of plasma corticosterone in vagotomized ratsCellular and Molecular Life Sciences, 1981
- Effect of caerulein on plasma corticosterone concentration in the ratLife Sciences, 1980
- Development of vasoactive intestinal polypeptide (VIP) containing neurones in the rat brainBrain Research, 1979
- Radioimmunologic localization of vasoactive intestinal polypeptide in hypothalamic and extrahypothalamic sites in the rat brainNeuroscience Letters, 1979
- Vasoactive intestinal peptide (VIP): Brain distribution, subcellular localization and effect of deafferentation of the hypothalamus in male ratsBrain Research, 1979
- Vasoactive intestinal polypeptide: Release into hypophyseal portal bloodLife Sciences, 1979
- Cholecystokinin (pancreozymin). 4. Synthesis and properties of a biologically active analog of the C-terminal heptapeptide with .epsilon.-hydroxynorleucine sulfate replacing tyrosine sulfateJournal of Medicinal Chemistry, 1978
- Vasoactive intestinal polypeptide in brain: localization in and release from isolated nerve terminals.Proceedings of the National Academy of Sciences, 1977
- Synthesis of (27-Tyr)-cholecystokinin-pancreozymin (CCK-PZ).CHEMICAL & PHARMACEUTICAL BULLETIN, 1975
- THE ESTIMATION OF SMALL AMOUNTS OF CORTICOSTERONE IN RAT PLASMAJournal of Biological Chemistry, 1958