Effects of tiagabine on cholecystokinin-tetrapeptide (CCK-4)-induced anxiety in healthy volunteers
- 12 November 2003
- journal article
- research article
- Published by Hindawi Limited in Depression and Anxiety
- Vol. 18 (3), 140-143
- https://doi.org/10.1002/da.10099
Abstract
There is increasing evidence that a dysregulation of the γ‐aminobutyric acid (GABA) system plays a role in the pathophysiology of panic disorder. Selective enhancement of GABAergic neurotransmission has been shown to improve anxiety in experimental animals and in patients with panic disorder. Tiagabine is an antiepileptic drug, which increases GABA via selective blockade of GABA reuptake. Apart from its anticonvulsant activity anxiolytic properties could therefore be suggested. To investigate the putative anxiolytic properties of the GABA reuptake blocker tiagabine, we studied the impact of tiagabine treatment on cholecystokinin tetrapeptide (CCK‐4)‐induced panic. Fifteen healthy volunteers received 15 mg tiagabine daily for 1 week. A CCK‐4 challenge was performed before and after treatment. Panic was assessed using the API‐ and PSS‐score. There was a marked improvement of CCK‐4‐induced panic after 1 week of treatment. Both API‐ and PSS‐scores showed a significant reduction. Our results suggest anxiolytic properties of tiagabine in humans, which provide sufficient rationale to assess its putative anxiolytic effects in patients with panic disorder under controlled conditions. Depression and Anxiety 18:140–143, 2003.Keywords
Funding Information
- Sanofi-Synthelabo, Germany
This publication has 17 references indexed in Scilit:
- Vigabatrin Decreases Cholecystokinin-Tetrapeptide (CCK-4) Induced Panic in Healthy VolunteersNeuropsychopharmacology, 2001
- Increased ACTH Concentrations Associated with Cholecystokinin Tetrapeptide-Induced Panic Attacks in Patients with Panic DisorderNeuropsychopharmacology, 2000
- Decreased Brain GABAA-Benzodiazepine Receptor Binding in Panic DisorderArchives of General Psychiatry, 1998
- Effect of the selective serotonin reuptake inhibitor fluvoxamine on CCK-4 induced panic attacksPsychopharmacology, 1997
- Update on the Mechanism of Action of Antiepileptic DrugsEpilepsia, 1996
- Anxiolytic-like effect of the GABA-transaminase inhibitor vigabatrin (gamma-vinyl GABA) on rat exploratory activityPharmacology Biochemistry and Behavior, 1994
- Pentagastrin infusions in patients with panic disorder II. NeuroendocrinologyBiological Psychiatry, 1994
- Valproate treatment of panic disorder and lactate-induced panic attacksBiological Psychiatry, 1993
- Replication of action of cholecystokinin tetrapeptide in panic disorder: clinical and behavioral findingsAmerican Journal of Psychiatry, 1992
- Measurement of lactate-induced panic and anxietyPsychiatry Research, 1987