Angiotensin II- and Angiotensin III-Induced Aldosterone Release in vivo in the Rat
- 31 May 1974
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 184 (4140), 994-996
- https://doi.org/10.1126/science.184.4140.994
Abstract
The potential role of angiotensin II and its heptapeptide metabolite, des-aspartyl-angiotensin II, was studied in the conscious unanesthetized rat. Aldosterone release was induced by both peptides at physiologic doses (0.72 nanogram per minute). [I-Sarcosyl-8-alanyl]-angiotensin II (P-113 inhibited angiotensin II more effectively than des-aspartyl-angiotensin II (101 percent as compared to 82 percent). These results indicate that angiotensin controls aldosterone release in the rat and that des-aspartyl-angiotensin II (that is, angiotensin III) may be important in this sequence.Keywords
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