Agglutinin Production in Normal, Sublethally Irradiated, and Lethally Irradiated Mice Treated with Mouse Bone Marrow

Abstract

Maximum agglutinin production was attained when the mice were 12 weeks of age. The optimum antigen dose to induce the maximum agglutinin response was found to be 1 ml of a 1.0% RBC suspension. Isologous bone marrow suspension protected 95% of the lethally x-irradiated mice (950 r). The ability to produce sheep agglutinin was recovered 30 days after the lethal irradiation-bone marrow treatment, whereas 60 days were required to produce rat agglutinin.