Processing of degradable ulvan 3D porous structures for biomedical applications
- 10 September 2012
- journal article
- research article
- Published by Wiley in Journal of Biomedical Materials Research Part A
- Vol. 101A (4), 998-1006
- https://doi.org/10.1002/jbm.a.34403
Abstract
The interest in ulvan within a biomedical framework increases as the knowledge of this polysaccharide evolves. Ulvan has been recently proposed as a potential biomaterial, and structures based on this polysaccharide are now being studied for different biomedical applications. In this work, a novel porous structure based on cross-linked ulvan was designed and characterized. Its mechanical performance, water-uptake ability and weight loss were assessed, morphology analyzed through scanning electron microscopy, and morphometric parameters quantified by microcomputed tomography. Cell viability and cell proliferation were evaluated in order to estimate the cytotoxicity of these structures and respective degradation products. Produced ulvan structures revealed remarkable ability to uptake water (up to ∼ 2000% of its initial dry weight) and are characterized by a highly porous and interconnected structure. Furthermore, these ulvan structures underwent nontoxic degradation, and cells remained viable through the time of culture. These results position ulvan structures as prospective blocks that can be further functionalized in order to acquire the desired stability and needed biological interactivity to be used as tissue-engineered structures. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2013.Keywords
This publication has 28 references indexed in Scilit:
- Control of Surface Chemistry, Substrate Stiffness, and Cell Function in a Novel Terpolymer Methacrylate LibraryLangmuir, 2011
- Fabrication of porous polysaccharide-based scaffolds using a combined freeze-drying/cross-linking processActa Biomaterialia, 2010
- Polymer Scaffolds for Biomaterials ApplicationsMacromolecules, 2009
- Synthesis and characterization of collagen/hyaluronan/chitosan composite sponges for potential biomedical applicationsActa Biomaterialia, 2009
- Preparation and characterization of chitosan/galactosylated hyaluronic acid scaffolds for primary hepatocytes cultureJournal of Materials Science: Materials in Medicine, 2009
- The effect of hyaluronic acid incorporation on fibroblast spreading and proliferation within PEG-diacrylate based semi-interpenetrating networksBiomaterials, 2007
- Natural–origin polymers as carriers and scaffolds for biomolecules and cell delivery in tissue engineering applicationsAdvanced Drug Delivery Reviews, 2007
- Polysaccharides as scaffolds for bone regenerationITBM-RBM, 2005
- Tissue Engineering: Key Elements and Some TrendsMacromolecular Bioscience, 2004
- The kinetics of 1,4-butanediol diglycidyl ether crosslinking of dermal sheep collagenJournal of Biomedical Materials Research, 2000