Formate and its role in hydrogen production in Escherichia coli
- 1 February 2005
- journal article
- Published by Portland Press Ltd. in Biochemical Society Transactions
- Vol. 33 (1), 42-46
- https://doi.org/10.1042/bst0330042
Abstract
The production of dihydrogen by Escherichia coli and other members of the Enterobacteriaceae is one of the classic features of mixed-acid fermentation. Synthesis of the multicomponent, membrane-associated FHL (formate hydrogenlyase) enzyme complex, which disproportionates formate into CO(2) and H(2), has an absolute requirement for formate. Formate, therefore, represents a signature molecule in the fermenting E. coli cell and factors that determine formate metabolism control FHL synthesis and consequently dihydrogen evolution.Keywords
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