Telomere Wedding Ends in Divorce
- 2 April 2004
- journal article
- editorial
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 304 (5667), 60-62
- https://doi.org/10.1126/science.1096809
Abstract
The separation of sister chromatids during mitosis depends on dissociation of proteins called cohesins, which hold the sister chromatids together, prompted by a protease called separase. In their Perspective, Azzalin and Lingner discuss new research (Dynek and Smith) revealing an additional type of cohesion between the ends of sister-chromatid telomeres that requires a separate enzyme called tankyrase 1 for separation during anaphase.Keywords
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