ANTITUBERCULOUS IMMUNITY INDUCED BY METHANOL EXTRACTS OF TUBERCLE BACILLI—ITS ENHANCEMENT BY ADJUVANTS

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Abstract
It is possible to prepare from tubercle bacilli a fraction soluble in methanol which is capable of eliciting in mice a marked degree of resistance against virulent tuberculous infection. The immunity was evident whether the infective dose was large and caused a disease with a rapid course, or was very small and caused a disease of many months duration.