INHIBITION OF SYMPATHOMIMETIC EFFECTS ON THE HEART
Open Access
- 1 October 1964
- journal article
- research article
- Published by Wiley in British Journal of Pharmacology and Chemotherapy
- Vol. 23 (2), 399-404
- https://doi.org/10.1111/j.1476-5381.1964.tb01596.x
Abstract
The adrenaline β-receptor blocking drug, pronethalol, and the sympathomimetic amines, (–)-ephedrine, (–)-amphetamine, dexamphetamine, (–)-Ω-ephedrine and tyramine, inhibited the sympathomimetic effects of butyrylcholine and tyramine on the guinea-pig isolated atrium. Being reversible and noncompetitive, this antagonism was unspecific and not due to blockade of adrenaline receptors, although pronethalol inhibited the effect of noradrenaline competitively.Keywords
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