Depression of Insulin Release by Anti-GIP Serum after Oral Glucose in Rats

Abstract
An oral glucose tolerance test (OGTT), an OGTT after infusion of antigastric inhibitory polypeptide (GIP) serum and an i.v. glucose infusion were performed in unrestrained and unanesthetized rats. In the rats treated with anti-GIP serum the insulin release was significantly depressed. GIP is apparently a physiologically important glucose-dependent insulin-releasing peptide.