Crystal-neutrophil interactions lead to interleukin-1 synthesis
- 1 September 1991
- journal article
- cytokines
- Published by Springer Nature in Inflammation Research
- Vol. 34 (1-2), 38-41
- https://doi.org/10.1007/bf01993232
Abstract
Normal human blood neutrophils were studied for their capacity to synthesize and release interleukin-1 (IL-1) species after phagocytosis of triclinic monosodium urate (MSU) and calcium pyrophosphate dihydrate crystals (CPPD). MSU crystals were more potent inducers of IL-1 generation than CPPD or unopsonized zymosan. Microcrystal-stimulated neutrophils characteristically secreted most of the newly synthesized IL-1. Colchicine partly inhibited the secretion of IL-1 by neutrophils during phagocytosis of solid particles. However, colchicine selectively inhibited IL-1 synthesis induced by microcrystals. These results suggest that neutrophil-derived IL-1 may contribute to the pathogenesis of crystal-induced arthritis.Keywords
This publication has 14 references indexed in Scilit:
- Crystal‐induced neutrophil activation. I. Initiation and modulation of calcium mobilization and superoxide production by microcrystalsArthritis & Rheumatism, 1991
- Production of monoclonal antibodies against interleukin-1α and -1βJournal of Immunological Methods, 1989
- Monosodium urate and calcium pyrophosphate crystals differentially activate the excitation-response coupling sequence of human neutrophilsBiochemical and Biophysical Research Communications, 1987
- Effect of synthetic calcium pyrophosphate and hydroxyapatite crystals on the interaction of human blood mononuclear cells with chondrocytes, synovial cells, and fibroblastsArthritis & Rheumatism, 1987
- Interleukin 1 production by human polymorphonuclear neutrophils.The Journal of Immunology, 1986
- Interleukin-1 and the Acute Phase Response in Acute Crystal SynovitisRheumatology, 1985
- Experimental inflammation induced by naturally occurring microcrystalline calcium salts.1976
- Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.1968
- The Glomerular Permeability Determined by Dextran Clearance Using Sephadex Gel FiltrationScandinavian Journal of Clinical and Laboratory Investigation, 1968