Large Doses of Radioiodine in the Treatment of Thyrotoxicosis

Abstract

Indications for the use of radioactive iodine in the treatment of hyperthyroidism, the proper treatment schedule and the attendant complications currently are undergoing widespread re-evaluation. This has been prompted in the main by the recognition that delayed post-radiation hypothyroidism is considerably more frequent than previously thought and is, in the view of many, too frequent to be tolerated within the entire population of patients to be treated for hyperthyroidism. Attention has been focused, therefore, on methods that would exploit the advantages of ¹³¹I therapy while decreasing the risk of hypothyroidism, mainly by reducing the dose of ¹³¹I.^{1 , 2} Such methods, however, . . .