A New Platelet Antigen System, Yuka/Yukb

Abstract

We report a new platelet antigen (Yuk^b) involved in a case of neonatal alloimmune thrombocytopenia (NAITP). This antigen is considered to be a product of an allele of the Yuk gene, another allele of which codes for Yuk^a which was involved in 2 cases of NAITP. The Yuk^a and Yuk^b antigens are not expressed on thrombasthenic platelets which suggests that these antigens are present on platelet glycoprotein IIb and/or IIIa. The gene frequencies for Yuk^a and Yuk^b in the Japanese population were estimated to be 0.0083 and 0.9917, respectively.